Senior Trial Team

Aamir Iqbal

Clinical Trial Coordination

Mr Iftakher Hossain

Senior Registrar Adjunct Professor of Neurosurgery, University of Turku, Finland Neurosurgery and Major Trauma Unit, Imperial College Healthcare NHS Trust

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Professor Peter Hutchinson

Senior Trial Team

Joint Lead Investigator Professor of Neurosurgery & Honorary Consultant Neurosurgeon University of Cambridge & Cambridge University Hospitals NHS Foundation Trust

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Mr Angelos Kolias

Senior Trial Team

Chief Investigator Clinical Senior Lecturer & Honorary Consultant Neurosurgeon University of Cambridge & Cambridge University Hospitals NHS Foundation Trust

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Statement of design

TOP-TBI is a multi-centre, parallel-group, pragmatic, randomised superiority trial to determine the clinical- and cost-effectiveness of early PTP administration versus late administration for adult patients with TBI. The study will be preceded by an internal pilot to confirm recruitment, randomisation, treatment, and follow-up assessments. We have defined robust progression criteria (section 8.3) based on recently published recommendations (30). On reaching the pre-defined success criteria, the internal pilot studies will run seamlessly into the main trial.

Senior Trial Team

Aamir Iqbal

Mr Iftakher Hossain

Professor Peter Hutchinson

Mr Angelos Kolias

Need Help?

We are here to help.

Statement of design

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